Sotalol, unlike the other beta‐blockers, increases the QT c interval and risk of torsades de pointes ventricular tachycardia in severe poisonings
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چکیده
منابع مشابه
Takotsubo cardiomyopathy and QT interval prolongation: who are the patients at risk for torsades de pointes?
OBJECTIVES QT interval prolongation is prevalent among patients with Takotsubo cardiomyopathy (TC), whereas torsades de pointes (TdP) has rarely been reported in these patients. We studied all peer-reviewed reports on TC-associated QT interval prolongation and all peer-reviewed reports on TC-associated TdP to characterize the clinical circumstances leading to TdP in patients with TC. METHODS ...
متن کاملDothiepin, Qt Prolongation and Torsades De Pointes
A case is reported of electrocardiographic QT prolongation that was presumbty familial in origin. Torsades de points developed in association with the use ofdothinepin, despite the pmscription of a low dose of this drug.
متن کاملManagement of prolonged QT interval and torsades de pointes in the intoxicated patient.
Many drugs can significantly influence cardiac repolarisation causing an increased duration of this repolarisation phase, challenging the repolarisation reserve. This may set the stage for life-threatening ventricular arrhythmias such as torsades de pointes (TdP). TdP generally occurs in conjunction with a prolonged QT interval (QT) on the electrocardiogram. The Dutch Poisons Information Centre...
متن کاملQT Interval Prolongation as a Biomarker for Torsades de Pointes and Sudden Death in Drug Development
Prolongation of the QT interval on the surface 12-lead electrocardiogram is widely accepted as a biomarker for the potential of a drug to produce torsades de pointes and/or sudden death. Detection of drug-induced prolongation of the QT interval in animals and man is frequently confounded by extrinsic and intrinsic factors that limit the ability to detect a true drug effect. In particular drugs ...
متن کاملDrug-Induced QT Prolongation And Torsades de Pointes.
Torsades de pointes (TdP)-an uncommon but life-threatening polymorphic ventricular tachycardia-is almost always drug induced. The authors describe the causes, risk factors, symptoms, diagnosis, and treatment of TdP.
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ژورنال
عنوان ژورنال: Basic & Clinical Pharmacology & Toxicology
سال: 2019
ISSN: 1742-7835,1742-7843
DOI: 10.1111/bcpt.13333